Publications

Graphical conditional generative modeling for digital twin modeling
Graphical conditional generative modeling for digital twin modeling
Authors: Zongren Zou, Theo Bourdais, Ricardo Baptista and Houman Owhadi
Published in: arXiv • June 2026
Digital Twins Generative Models Sensitivity Analysis Machine Learning

A framework for discovering which inputs shape the full conditional law of a target—beyond the conditional mean—for parsimonious digital-twin surrogates.

ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks
ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks
Authors: Zhizhen Zhang, Hyemin Gu, Benjamin J. Zhang, Daniel Elenius, Michael Tyrrell, Theo J. Bourdais, Houman Owhadi, Markos A. Katsoulakis and Tuhin Sahai
Published in: arXiv • May 2026
Digital Twins Supply Chain Simulation Forecasting

A public multi-echelon logistics digital twin for simulation, dataset generation, and forecasting benchmarks, with interpretable controls and verification tools.

Operator Learning at Machine Precision
Operator Learning at Machine Precision
Authors: Aras Bacho, Aleksei G. Sorokin, Xianjin Yang, Theo Bourdais, Edoardo Calvello, Matthieu Darcy, Alexander Hsu, Bamdad Hosseini and Houman Owhadi
Published in: arXiv • November 2025
Operator Learning Scientific Computing Neural Operators Machine Learning

CHONKNORIS achieves machine-precision operator learning by regressing Cholesky factors of Newton–Kantorovich updates rather than the solution operator itself.

Discovering Algorithms with Computational Language Processing
Discovering Algorithms with Computational Language Processing
Authors: Theo Bourdais, Abeynaya Gnanasekaran, Houman Owhadi and Tuhin Sahai
Published in: arXiv • July 2025
Algorithm Discovery Reinforcement Learning Combinatorial Optimization Quantum Computing

A computational-token framework with RL-guided search that rediscovers and invents algorithms for combinatorial optimization and quantum computing.

Pruning Deep Neural Networks via a Combination of the Marchenko-Pastur Distribution and Regularization
Pruning Deep Neural Networks via a Combination of the Marchenko-Pastur Distribution and Regularization
Authors: Leonid Berlyand, Theo Bourdais, Houman Owhadi and Yitzchak Shmalo
Published in: arXiv • March 2025
Deep Learning Neural Network Pruning Random Matrix Theory Vision Transformers

We use Random Matrix Theory and regularization to prune deep neural networks, achieving state-of-the-art results on ImageNet with Vision Transformers. We also provide theoretical justification for our approach.

Codiscovering graphical structure and functional relationships within data: A Gaussian Process framework for connecting the dots
Codiscovering graphical structure and functional relationships within data: A Gaussian Process framework for connecting the dots
Authors: Theo Bourdais, Pau Batlle, Xianjin Yang, Ricardo Baptista, Nicolas Rouquette and Houman Owhadi
Published in: PNAS • November 2023
Gaussian Processes Hypergraphs Machine Learning Computational Science

This paper introduces Computational Hypergraph Discovery (CHD), a novel method for uncovering unknown functional relationships between variables within datasets, and represent them using a hypergraph.

Development and Assessment of an Artificial Intelligence-Based Tool for Ptosis Measurement in Adult Myasthenia Gravis Patients Using Selfie Video Clips Recorded on Smartphones
Development and Assessment of an Artificial Intelligence-Based Tool for Ptosis Measurement in Adult Myasthenia Gravis Patients Using Selfie Video Clips Recorded on Smartphones
Authors: Meelis Lootus, Lulu Beatson, Lucas Atwood, Theo Bourdais, Sandra Steyaert, Chethan Sarabu, Zeenia Framroze, Harriet Dickinson, Jean-Christophe Steels, Emily Lewis, Nirav R Shah and Francesca Rinaldo
Published in: Digital Biomarkers • May 2023
Computer Vision Medical AI Myasthenia Gravis Mobile Health

My first paper! This paper describes the work we did at Doc.ai for ShareCare on Myasthenia gravis (MG) with UCB. We developed a Deep Learning model based on ResNet50 to predict a key symptom of MG via selfie. This would allow clinical trials to accept more patients as part of a study in order to scale it, as well as follow almost in real time the evolution of a patient's symptoms using an app on their phone.